Project acronym: ECHA/2022/502.Lot 2

Project duration: 8th Sept 2023- 8th Sept 2029

Project coordinator: QSAR LAB Ltd., Poland

Our role: Leader group for in vitro and in vivo toxicology

Funded by: European Chemical Agency (ECHA)

Total budget: 1 800 000,00 EUR

Abstract:

The primary objective of this Framework Contract (FWC) is to provide services related to methodological developments and data generation for the assessment and building of sets of nanoforms, and to support ECHA in its tasks.

  1. The overarching goal of this project is to focus on addressing the need for the development and further improvement of the framework for identity/similarity criteria for sets of nanoforms. The Consortium participating in this project brings together experts in the synthesis and physicochemical characterization, toxicity, and ecotoxicity assessment of nanomaterials, as well as machine learning and artificial intelligence approaches. It offers its services in the development, validation, and implementation of a new framework supported by New Approach Methodologies (NAMs). The Consortium also provides consultancy services related to NAMs and their regulatory implementation for nanoforms by preparing review reports in relevant research areas, conducting case studies using both experimental and in silico approaches, and organizing surveys and workshops with experts and representatives from key stakeholder groups: regulatory, industrial, and academic communities.
  1. Furthermore, the Consortium proposes the preparation of a comprehensive workflow with a timeline for the development, validation, and implementation of a new framework for identity/similarity assessments of sets of nanoforms. The Consortium’s ambition is to deliver a scientifically valid and regulatorily relevant framework supported by NAMs, enabling reliable safety assessment and registration of nanoforms while remaining sustainable and beneficial for the industry.

Project partners:

QSAR LAB Ltd., Poland

University of Lodz, Poland

Institute for Medical Research and Occupational Health, Croatia

European Regional Centre for Ecohydrology of the Polish Academy of Sciences (ERCE
PAS), Poland