Description and advantages:
- Only human tissue based assay which accurately predicts human toxicity and clinical response
- New approach methods (NAMs) and in vitro alternatives
- Higher throughput pre-clinical sensitisation testing of chemicals, biologics, and cosmetics. Outsourcing partner for molecular analysis, large range of molecular techniques available, cell culture is our core expertise
- Development of complex and functional high-throughput in-vitro 3D tissue models for replicating disease states and high-throughput molecule screening
- Assays give insight to mode of action (MoA) and knowledge into potential therapeutic failure and preventative measures
- More specific, shows actual tissue damage including systemic toxicity, adverse immune reactions, hypersensitivity
Capabilities:
- Hemocompatiblity testing
- Oncology platform using 3D tumor models
- Biological barriers (intestinal, placental, endothelial and blood-brain)
- Mitochondrial functionality and toxicity
- Endocrine disruption using OECD test guidlines
- Flow cytometry analysis
- Live-cell imaging
- Cell culture expertise
- Immunohistochemistry & immunocytochemistry
- ELISA
- RNA extraction and RT-PCR